Primary Tumor

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Filter the dataset further by tumor-specific details, like the lateralization of a patient's primary tumor, its location and/or T-category.

Next to the selected subsites and T-categories, this panel also displays how many patients presented with a tumor in the respective subsite / T-category.

Note: Both the subsites and T-categories are selected or deselected by clicking on the respective button. If it appears white on dark blue, it is selected. If it appears dark blue on light blue, it is deselected. For example, selecting 'T1' and 'T2' and 'Tonsil' will select all patients that have primary tumors located in the tonsil AND are T1 OR T2-category, i.e. different criteria are combined via AND operations whereas T-categories are connected via OR operations.

63
434
921
269
376
773

T-Category

5
319
479
257
358

Location & Subsite

Base of Tongue
Tongue
Gum
Floor of Mouth
Palate
Cheek
Tonsil
Oropharynx
Hypopharynx
Larynx

Patient details

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In this panel, one can narrow down the subset of selected patients based on criteria that characterize the patient as a whole, such as HPV status or whether they are smokers. To do so, put the toggle buttons in one of the following three states:

  • Only patients are selected where the respective characterisitc is *positive*. E.g. in the case of "smoking status" this would select all smokers.
  • This selection means that no filtering will be performed regarding the corresponding patient characteristic.
  • Selecting this will only include patients in the subset that do not have the respective characteristic or it is negative (e.g. not-smoking or HPV negative).

Note: Just below the buttons there are three numbers that give a preview of how many of the currently selected patients can be categorized according to the respective characteristic. Here, the middle number indicates for how many patients the characteristic is unknown.

Note: All filters in the Patient characteristics panel are combined via AND operations. This means, if one selects + for HPV status and - for neck dissection, the selection includes only patients who are HPV positive AND did not receive neck dissction.

Warning: Dont forget to hit compute after you have changed your selection criteria.

1077
0
341
625
334
459
1050
0
368
1001
0
417

Datasets

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Since we collect and visualize datasets from different institutions here, one can of course select which ones should be considered. To do so, simply click on the respective institution's logo. It is selected, if the logo is outlined and deselected if it is not.

Modalities

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Choose which of the available modalities to include in the visualization. Only patients are considered that have at least one of the selected diagnoses available. One may choose how to combine these - possibly conflicting - diagnoses:

  • logical OR: A lymph node level (LNL) is reported as metastatic or involved as soon as one of the selected diagnoses reports a positive finding. Anything else is reported as healthy.
  • logical AND: LNL's are reported as involved only when all diagnoses agree on positive findings. If that is not the case, meaning that none or not all agree on such a finding, it is reported (rather optimistically) as healthy.
  • maxLLH: This computes the most likely involvement based on all available diagnostic modalities and their respective sensitivities & specificities for a patient.
  • rank: Similar to the maxLLh method, this uses the sensitivities & specificities of the available diagnostic modalities, but instead of combining all diagnoses into one, it accepts the most trustworthy diagnose for a given patient.

The sensitivities & specificities used are listed below:

Modality Specificity Sensitivity
% %
% %
% %
% %
% %
% %
% %

contralateral

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Here the most important information is visualized. For each side of the neck (ipsilateral being the same side as the tumor, contralateral the opposite) it displays a row for each LNL. From left to right, that row consists of...

  • its roman numeral label (e.g. IV)
  • a three-way toggle-button to select a subset of patients that show metastases in that LNL () or are reported healthy (). Selecting the middle button () means that no filtering is performed
  • and a horizontal stacked bar that displays the ratio of patients with reports of metastases in that LNL to patients that appear to have a healthy LNL. Numbers to the left and right of that bar plot indicate the absolute numbers and give a brief explanation when hovering over them with the mouse pointer.

Note: If for some patients the involvement in a LNL is unknown, these patients are represented by the middle bar. This may for example occur when selecting FNP is diagnostic modality, which is performed only in selected LNL.

LNL select involvement (metastatic, unknown, healthy)
I both
30 1388
a
3 1415
b
30 1388
II both
170 1248
a
107 51 1260
b
50 51 1317
III
70 1348
IV
28 1 1389
V both
23 1 1394
a
3 17 1398
b
4 17 1397
VII
12 967 439

ipsilateral

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Here the most important information is visualized. For each side of the neck (ipsilateral being the same side as the tumor, contralateral the opposite) it displays a row for each LNL. From left to right, that row consists of...

  • its roman numeral label (e.g. IV)
  • a three-way toggle-button to select a subset of patients that show metastases in that LNL () or are reported healthy (). Selecting the middle button () means that no filtering is performed
  • and a horizontal stacked bar that displays the ratio of patients with reports of metastases in that LNL to patients that appear to have a healthy LNL. Numbers to the left and right of that bar plot indicate the absolute numbers and give a brief explanation when hovering over them with the mouse pointer.

Note: If for some patients the involvement in a LNL is unknown, these patients are represented by the middle bar. This may for example occur when selecting FNP is diagnostic modality, which is performed only in selected LNL.

LNL select involvement (metastatic, unknown, healthy)
I both
166 1252
a
13 1405
b
157 1261
II both
819 599
a
438 337 643
b
194 336 888
III
372 1046
IV
107 1311
V both
100 1318
a
16 60 1342
b
7 60 1351
VII
59 703 656
Help
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From left to right the three buttons here are

  • the help button in light blue, opening this very menu
  • an info button in light orange that shows how many patients are in the currently narrowed-down subset and that redirects to a list of patients in that subset when pressed
  • the compute button in bright orange, which sends a request with the current selections to the server for an update of the visualized statistics

Finally, on the left in this box one can toggle between displaying absolute numbers or percentages.